Polymorphisms in α-Defensin–encoding DEFA1A3 associate with urinary tract infection risk in children with vesicoureteral reflux
AL Schwaderer, H Wang, SH Kim… - Journal of the …, 2016 - journals.lww.com
The contribution of genetic variation to urinary tract infection (UTI) risk in children with
vesicoureteral reflux is largely unknown. The innate immune system, which includes
antimicrobial peptides, such as the α-defensins, encoded by DEFA1A3, is important in
preventing UTIs but has not been investigated in the vesicoureteral reflux population. We
used quantitative real–time PCR to determine DEFA1A3 DNA copy numbers in 298
individuals with confirmed UTIs and vesicoureteral reflux from the Randomized Intervention …
vesicoureteral reflux is largely unknown. The innate immune system, which includes
antimicrobial peptides, such as the α-defensins, encoded by DEFA1A3, is important in
preventing UTIs but has not been investigated in the vesicoureteral reflux population. We
used quantitative real–time PCR to determine DEFA1A3 DNA copy numbers in 298
individuals with confirmed UTIs and vesicoureteral reflux from the Randomized Intervention …
