Mesenchymal stem cells (MSCs) are multipotent cells with critical roles in homeostasis and
regeneration. MSCs undergo aging in response to various stresses, and this causes many
diseases including degenerative disorders. Thus, regulation of aging factors is crucial for
healthy aging. Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) was recently
reported to regulate metabolic homeostasis. Here, we investigated the restorative effects of
MOTS-c on aged human placenta-derived MSCs (hPD-MSCs). MOTS-c promoted the …