Commentary 10.1172/JCI128371

Human T cell repertoire: what happens in thymus does not stay in thymus

Antonio La Cava

Department of Medicine, UCLA, Los Angeles, California, USA.

Address correspondence to: Antonio La Cava, 1000 Veteran Avenue 32-59, Department of Medicine, UCLA, Los Angeles, California 90095, USA. Phone: 310.267.4975; Email: alacava@mednet.ucla.edu.

Find articles by La Cava, A. in: JCI | PubMed | Google Scholar

First published May 13, 2019 - More info

Published in Volume 129, Issue 6 on June 3, 2019
J Clin Invest. 2019;129(6):2195–2197. https://doi.org/10.1172/JCI128371.
© 2019 American Society for Clinical Investigation
First published May 13, 2019 - Version history

The T cell receptor (TCR) repertoire is diverse, thus allowing recognition of a wide range of pathogens by T cells. In humans, the study of the formation of TCR repertoires is problematic because of the difficulty in performing investigations in vivo. In this issue of the JCI, Khosravi-Maharlooei and colleagues describe a new humanized mouse model that allows direct investigations on this topic. Using high-throughput and single-cell TCR–complementarity-determining region 3 β (TCR-CDR3β) sequencing, the authors were able to demonstrate that human thymic selection is a major driver of TCR sequence sharing, also implicating a preferential selection of shared cross-reactive CDR3βs during repertoire formation.

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